发明名称 |
Tumor suppressor designated TS10Q23.3 |
摘要 |
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
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申请公布号 |
US6262242(B1) |
申请公布日期 |
2001.07.17 |
申请号 |
US19970791115 |
申请日期 |
1997.01.30 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;MYRIAD GENETICS, INC. |
发明人 |
STECK PETER;PERSHOUSE MARK A.;JASSER SAMAR A.;YUNG W. K. ALFRED;TAVTIGIAN SEAN V. |
分类号 |
A01K67/027;A61K38/00;A61K48/00;A61P35/00;A61P35/02;C07K14/47;C07K16/18;C12N5/10;C12N9/16;C12N15/09;C12N15/12;C12P21/08;C12Q1/02;C12Q1/68;C12R1/91;G01N33/574;(IPC1-7):C07H2/04;C07K14/475 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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