| 摘要 |
PROBLEM TO BE SOLVED: To provide a non-peptide-based antagonist of B2 receptor, having B2 antagonist activities and metabolic stability to the human liver microsome. SOLUTION: This substituted 1,4-dihydropyridine compound is a compound represented by the general formula (I) [A is independently a halogen; Y is (CH2)m, C(O) or S(O); R1 and R2 are each independently a 1-4C alkyl; R3 is a 7-9C bicycloalkyl, a 5-7C azacycloalkyl, a 7-9C azabicycloalkyl or the like; R4 is thiazolyl, imidazolyl, oxazolyl or the like; R5 is H or a 1-4C alkyl; m is 0, 1 or 2; n is 0, 1, 2, 3, 4 or 5] or a pharmaceutically acceptable salt thereof. The pharmaceutical composition contains the compound.
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