发明名称 Piperidone tachykinin antagonists
摘要 The present invention provides compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein X is a direct link or C1-C4 alkylene; and R is C3-C7 cycloalkyl optionally substituted by 1 or 2 substituents each independently selected from fluoro and C3-C7 cycloalkyl: with the proviso that X is not methylene when R is cyclopropyl, together with processes for the preparation of, intermediates used in the preparation of, compositions containing and uses of, such compounds. These compounds are useful as tachykinin antagonists.
申请公布号 US6262075(B1) 申请公布日期 2001.07.17
申请号 US19980117011 申请日期 1998.07.20
申请人 PFIZER INC 发明人 MACKENZIE ALEXANDER RODERICK;MARCHINGTON ALLAN PATRICK;MIDDLETON DONALD STUART;MEADOWS SANDRA DORA
分类号 A61K31/4427;A61K31/445;A61K31/4545;A61P1/00;A61P3/08;A61P11/00;A61P25/00;A61P25/02;A61P29/00;A61P37/08;A61P43/00;C07D401/14;(IPC1-7):A61K31/454 主分类号 A61K31/4427
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