发明名称 |
Water soluble paclitaxel prodrugs |
摘要 |
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.
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申请公布号 |
US6262107(B1) |
申请公布日期 |
2001.07.17 |
申请号 |
US19990346263 |
申请日期 |
1999.07.01 |
申请人 |
PG-TXL COMPANY L.P. |
发明人 |
LI CHUN;WALLACE SIDNEY;YU DONG-FANG;YANG DAVID J. |
分类号 |
A61K31/335;A61K31/337;A61K31/47;A61K31/4738;A61K31/4745;A61K31/70;A61K31/7042;A61K31/7048;A61K47/48;A61K51/00;A61K51/04;A61L31/10;A61L31/16;A61P9/00;A61P35/00;A61P37/02;A61P43/00;(IPC1-7):A01N43/02;C07D305/00;A61B5/055 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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