发明名称 |
MONOCLONAL ANTIBODIES FOR INDUCING TOLERANCE |
摘要 |
The present invention relates to the use of a non-depleting anti-CD4 monoclonal antibody for the manufacture of a medicament for the induction of a state of immunological tolerance to an antigen by a method which comprises administering said non-depleting anti-CD4 monoclonal antibody to a subject together with a non-depleting anti-CD8 monoclonal antibody to induce an immunological tolerance permissive environment within said subject by means of said antibodies in the presence of said antigen. Also, the invention relates to a pharmaceutical composition in unit dose form com- prising from 1 to 400 mg per unit dose of a non-deplet- ing anti-CD4 antibody or a non-depleting anti-CD8 anti- body together with a pharmaceutically acceptable car- rier or diluent in a form suitable for administration to a human subject.
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申请公布号 |
CA2055615(C) |
申请公布日期 |
2001.07.17 |
申请号 |
CA19902055615 |
申请日期 |
1990.05.31 |
申请人 |
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发明人 |
COBBOLD, STEPHEN PAUL;WALDMANN, HERMAN |
分类号 |
A61K39/395;A61K38/00;A61P37/06;C07K16/28;C12N5/00;C12N5/10;C12N15/02;C12P21/02;C12P21/08;C12R1/91;(IPC1-7):C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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