| 摘要 |
Compounds of formula (1a) or (1b) or salts thereof, wherein Z is N or CH; wherein n is 0 or 1; X<1> and X<2> are linkers; Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic rings, and Cy represents one or two substituted or unsubstituted aliphatic cyclic or heterocyclic moieties, or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic moiety and one substituted or unsubstituted aromatic or heteroaromatic moiety, Y is O, S, NR or CR2 where R is H or alkyl (1-6C); each 1<1> and 1<2> is independently 0-4; 1<3> is 0 or 1; each of R<1>, R<2> and R<3> is independently alkyl (1-6C), aryl (6-10C) or arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or may independently be halo, OR, SR, NR2, OOCR, NROCR, COR, COOR, CONR2, CF3, CN or NO2, wherein R is H or alkyl (1-6C), and wherein the dotted lines represent optional pi -bonds, or compounds of formulas (1a) or (1b) where (X<2>)nAr or (X<2>)n Cy is replaced by alkyl (1-6C) are useful in methods to block calcium channels. |
