发明名称 |
METHOD FOR MAKING INSULIN PRECURSORS AND INSULIN PRECURSOR ANALOGUES HAVING IMPROVED FERMENTATION YIELD IN YEAST |
摘要 |
Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 ANGSTROM .
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申请公布号 |
WO0149870(A1) |
申请公布日期 |
2001.07.12 |
申请号 |
WO2000DK00664 |
申请日期 |
2000.12.04 |
申请人 |
NOVO NORDISK A/S |
发明人 |
KJELDSEN, THOMAS, BOERGLUM;LUDVIGSEN, SVEND |
分类号 |
C12N15/09;C07K14/00;C07K14/62;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/17;C12P21/02;C12R1/645;(IPC1-7):C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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