| 摘要 |
<p>The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement of HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cyctic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, comeal ulcers, and invasion behaviour of malignant tumors.</p> |
