PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION

摘要

The invention relates to the use of multilamellar vesicles which comprise a lamellar liquid crystal internal structure made up of amphiphilic agent-based concentric bylayers alternated with layers of water, aqueous solution or a solution of a polar liquid; from the center to the periphery of the vesicles, and in which at least one active agent is incorporated, for producing an orally administered pharmaceutical composition. Said vesicles act as vectors of the active agent and enable said active agent to cross the gastro-intestinal barrier more easily. The vesicles also protect the active agent from decomposition, especially decomposition by the enzymes present in the gastro-intestinal environment. The invention also relates to novel compositions for oral administration, especially compositions containing heparin, incorporated in vesicles such as those described above.