| 摘要 |
PURPOSE: Provided is a racemization of R,S-dioxo-benzylpyrrolopiperidine by treating it with stoichiometric amount in a less amount than stoichiometry amount.The racemic compound obtained through this method can be reused in the production of a quinolone derivative. CONSTITUTION: The compound is racemized by treating (1R, 6S)-8- benzyl-7,9-dioxo-2,8-diazabicyclo(4.3.0)-nonane using a base (for example, potassium tert-butoxide) in the stoichiometry amount or less, in a solvent such as tetrahydrofuran, preferably under exclusion of oxygen, at preferably -10 to 30, preferably 40 deg.C. The amount of the component B to be used is preferably 3 to 10 mol% based on the (1R, 6S)-8- benzyl-7,9-dioxo-2,8-diazabicyclo(4.3.0).
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