Morpholine derivatives, process of their preparation and pharmaceutical preparation in which they are comprised

摘要

The present invention relates to morpholine derivatives of the general formula I, in which the individual symbols have specific meaning. These substances antagonize receptors of tachykinins and they can be therefore used for treating and prevention of diseases for which this antagonizing is required. In the present invention there are also claimed a process for preparing these compounds as well as pharmaceutical preparation in which they are comprised and that is intended for use particularly when treating inflammatory diseases, painful states, migraine and asthma and where it is necessary to block calcium channels, particularly in case of heart and vascular diseases such as angina pectoris, blood hypertension and ischemia.