发明名称 |
Targeted immunostimulation with bispecific reagents |
摘要 |
Disclosed are methods of stimulating in a subject an immune response to an antigen to which the immune response is targeted. This method includes the step of administering to the subject a binding agent which binds a surface receptor of an antigen-presenting cell, in some instances without being blocked substantially by the natural ligand for the surface receptor, and an antigen to which the immune response is targeted, in a physiologically acceptable medium to the subject. Also disclosed are molecular complexes including the binding agent coupled to an antigen.
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申请公布号 |
US6258358(B1) |
申请公布日期 |
2001.07.10 |
申请号 |
US19950453500 |
申请日期 |
1995.05.30 |
申请人 |
MEDAREX, INC. |
发明人 |
ROMET-LEMONNE JEAN LOUP;FANGER MICHAEL W.;GUYRE PAUL M.;GOSSELIN EDMUND J. |
分类号 |
A61K39/00;A61K47/48;C07K16/28;C07K16/46;C12P21/08;(IPC1-7):A61K39/395;A61K38/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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