Activation and inhibition of the immune system

摘要

Induction of an anergic response by NF-ºB inhibitors and the inhibition of immune response by the administration of an inhibitor of NF-ºB is disclosed. Examples ofNF-ºB inhibitors include IºB±, PSI, a nucleotide encoding IºB± anti-sense nucleic acid encoding an NF-ºB sequence, such as RelB, and anti- NF-ºB antibodies. Also disclosed are vectors encoding inducers and inhibitors of NF-ºB, for example adenoviral vectors.