3-NITROPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: The 3-nitropyridine derivatives and a pharmaceutical composition containing the same are provided, which are useful for inhibiting the growth of hepatitis B virus(HBV) and human immunodeficiency virus(HIV). CONSTITUTION: The 3-nitropyridine derivatives are represented by formula (1), in which R1: is H; hydroxy; C2 to C6 dialkylamino; C2 to C6 linear or branched hydroxyalkyl; C3 to C6 linear or branched dihydroxyalkyl; C3 to C6 alkoxyalkyl; saturated or unsaturated hetero ring compound of 5 or 6 atoms that contains 1 to 3 hetero atoms selected from N, O or S and substituted or unsubstituted by C1 to C3 alkyl; and R1 contains as an asymmetric carbon, R2: is H; or C1 to C4 linear or branched alkyl, or R1 and R2 together form saturated membered hetero ring of 5 or 6 atoms, wherein the hetero ring contains 1 to 3 hetero atoms selected from N, O and S and substituted or unsubstituted by C1 to C5 linear or branched alkyl, C2 to C5 linear or branched hydroxyalkyl, or hydroxy, R3: is indazole-5-il or indazole-6-il, and n is an integer of 0 to 3. The pharmaceutical composition contains effective amounts of 3-nitropyridine derivatives.