| 摘要 |
PURPOSE: Provided is a process for producing N-acyl amino acid amide, which process is characterized in that the condensation reaction is conducted in the presence of a boron compound as catalyst and of an alcohol as an auxiliary solvent. CONSTITUTION: The process for producing an N-acyl amino acid amide comprises a condensation reaction of an N-acyl amino acid with an amine and/or an ammonia, preferably a primary amine, a secondary amine and/or an ammonia under dehydration in the presence of a boron compound as the catalyst and of an alcohol as an auxiliary solvent. The N-acyl amino acid amide can be produced at a high yield and in a short time. A medium for hylotropic dehydration such as hydrocarbon compounds may optionally additionally be used in the reaction.
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