| 摘要 |
BH4-fused polypeptides which contain the amino acid sequence of a polypeptide capable of exerting an effect of enabling uptake into cells or a derivative sequence thereof, and an amino acid sequence selected from the group consisting of: (A) amino acid sequences at least containing the BH4 domain sequence (SEQ ID NO:1) of an anti-apoptosis Bc1-2 family protein, (B) amino acid sequences derived from the amino acid sequence represented by SEQ ID NO:1 by substitution, deletion or insertion of at least one amino acid residue, and (C) amino acid sequences having a sequence homology of at least 50% with the amino acid sequence represented by SEQ ID NO:1, and are capable of inhibiting apoptosis; apoptosis inhibitors containing these BH4-fused proteins; a method of treating ischemic diseases which comprises administering these apoptosis inhibitors to patients with ischemic diseases to thereby inhibit apoptosis and treat the ischemic diseases; and use of the BH4-fused proteins for producing preventives or remedies for ischemic diseases. Thus, apoptosis can be efficiently inhibited and it is expected that the BH4-fused proteins are applicable to remedies for AIDS, neurodegenerative diseases, myelodysplastic diseases, ischemic diseases, infective multiple failure, fulminant hepatitis, diabetes, etc.
|
