| 摘要 |
<p>Fused purine derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, wherein X--Y--Z represents R1N-C=O (wherein R1 is hydrogen, lower alkyl, or the like) or N=C-W (wherein W is halogeno, an aromatic heterocyclic group, an aliphatic heterocyclic group, or the like); R2 is hydrogen, lower alkyl, aralkyl, aryl, an aromatic heterocyclic group, an aliphatic heterocyclic group, or the like; R3 is hydrogen, lower alkyl, aralkyl, or the like; n is an integer of 0 to 3; V1 is hydrogen, lower alkyl, aralkyl, aryl, or an aromatic heterocyclic group; and V2 is substituted lower alkyl or an aromatic heterocyclic group, with the proviso that V2 may represent lower alkyl, aralkyl, or aryl in, e.g., cases wherein V1 is hydrogen, lower alkyl, aralkyl, or aryl; X--Y--Z is R1aN-C=O (wherein R1a is the same as defined for R1, except substituted lower alkyl); and R2 is substituted lower alkyl, aralkyl, or an aliphatic heterocyclic group.</p> |
