摘要 |
The present invention is related to non-parenteral multiparticulate formulations capable of transporting therapeutic, prophylactic and diagnostic agents across mucosal membranes such as gastrointestinal, buccal, nasal, rectal and vaginal. Formulations comprise a plurality of carrier particles, an agent to be delivered across a mucosal membrane, and a penetration enhancer. The drug is adhered to the surface of the carrier particle or is impregnated within by electrostatic, covalent or mechanical forces.
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申请人 |
ISIS PHARMACEUTICALS, INC.;HARDEE, GREGORY, E.;TILLMAN, LLOYD, G.;MEHTA, RAHUL, C.;TENG, CHING-LEOU |
发明人 |
HARDEE, GREGORY, E.;TILLMAN, LLOYD, G.;MEHTA, RAHUL, C.;TENG, CHING-LEOU |