| 摘要 |
<p>Methods are provided for in vivo administration of a pain-relieving drug, such as a local anesthetic (e.g. lidocaine), to an interior disease site for pain relief at the interior disease site. In the invention pain treatment methods, a subject is administered a targeting construct comprising a biologically compatible pain-relieving agent and a tumor-avid ligand or monoclonal antibody that preponderantly binds to or is taken up by the tissue associated with an interior disease site. Administration is by a method other than topical injection or application, such as parenteral injection. Because the pain-relieving agent is delivered by the ligand to the disease site, intractable pain situated in the interior of the body, such as is caused by various tumors, can be managed using a lower level of the pain-relieving agent then is required when the pain-relieving agent is injected in the free state.</p> |
