| 摘要 |
<p>This invention relates to methods which provide protection against, or reduce the severity, of HIV infections and associated deleterious effects. More particularly it relates to methods of using peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, and/or carrier-conjugates thereof, or antibodies which bind to those peptides, to reduce, inhibit or eliminate stimulation of blastogenesis of monocytes, including T cells, by HIV Nef protein or other superantigen, and to reduce, inhibit or eliminate HIV replication. The invention also relates to methods using isolated and purified nucleic acids encoding the peptides of the invention, or transformed host cells containing those nucleic acids, to produce peptides which are useful in the methods of the invention.</p> |
