发明名称 |
HUMAN HEPARANASE-RELATED POLYPEPTIDE AND NUCLEIC ACID |
摘要 |
The present invention relates to newly identified polynucleotides, and polypeptides encoded by such polynucleotides, the use of such polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, a polypeptide of the present invention is a heparanase-related endoglucuronidase. The invention also relates to vectors and host cells comprising a polynucleotide of the invention. Furthermore, the invention relates to antibodies directed to polypeptides according to the present invention and to pharmaceutical compositions and diagnostic reagents comprising such antibodies, polypeptides or polynucleotides. The invention further relates to a method of altering, modifying or otherwise modulating the level of expression of the heparanase-related endoglucuronidase in a cell or in a organism. A further aspect of the invention are assay systems suitable for identifying modulators, e.g. agonists or antagonists of such polypeptides.
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申请公布号 |
WO0148161(A2) |
申请公布日期 |
2001.07.05 |
申请号 |
WO2000EP12909 |
申请日期 |
2000.12.18 |
申请人 |
SCHERING AKTIENGESELLSCHAFT;SIEMEISTER, GERHARD;WEISS, BERTRAM |
发明人 |
SIEMEISTER, GERHARD;WEISS, BERTRAM |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K39/395;A61K48/00;A61P15/00;A61P29/00;A61P35/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/24;(IPC1-7):C12N9/00 |
主分类号 |
C12N15/09 |
代理机构 |
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