发明名称 USE OF A NATIVE EPITOPE FOR SELECTING EVOLVED BINDING MEMBERS FROM A LIBRARY OF MUTANTS OF A PROTEIN CAPABLE OF BINDING TO SAID EPITOPE
摘要 The invention provides a method for selecting at least one member from a library of proteinaceous molecules comprising providing at least one cell and/or a functional equivalent thererof, with at least part of said library under conditions that allow binding of any such member to an epitope in and/ or on said cells and/or said functional equivalent thereof, removing unbound proteinaceous molecules and selecting said at least one member, wherein said library comprises at least one mutant of a proteinaceous molecule capable of binding to said epitope.
申请公布号 CA2396029(A1) 申请公布日期 2001.07.05
申请号 CA20002396029 申请日期 2000.12.21
申请人 CRUCELL HOLLAND B.V. 发明人 LOGTENBERG, TON
分类号 G01N33/53;A61K38/00;A61K39/395;A61P35/00;C07K1/14;C07K16/00;C07K16/28;C07K16/30;C12N15/09;C12P21/08;C12Q1/02;G01N33/68;(IPC1-7):G01N33/68 主分类号 G01N33/53
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