发明名称 |
METHOD FOR MANUFACTURING 5-(HYDROXY-PROTECTED)-5-(SUBSTITUTED OR UNSUBSTITUTED)2,3-ANHYDRO-2-DEOXYURIDINE COMPOUND |
摘要 |
PURPOSE: Provided is a method for manufacturing 5-(hydroxy-protected)-5-(substituted or unsubstituted)2,3-anhydro-2-deoxyuridine compound in a high yield which is useful as an intermediate of a compound useful in treating acquired immune deficiency syndrome (AIDS). CONSTITUTION: The method for manufacturing 5-(hydroxy-protected)-5-(substituted or unsubstituted)2,3-anhydro-2-deoxyuridine compound is characterized by the next step of: reacting 5-(hydroxy protected)-5-(substituted or unsubstituted)-2-deoxyuridine of the formula (4) with 1,1-sulfonyldiimidazole of the formula (3) in the presence of base and polar or nonpolar organic solvent at 0-150 deg.C, preferably 25-90 deg.C. Optionally, 1.2-2.0 equivalents of the compound (3) are added per 1 equivalent of the compound (4) to improve its yield more.
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申请公布号 |
KR20010056060(A) |
申请公布日期 |
2001.07.04 |
申请号 |
KR19990057477 |
申请日期 |
1999.12.14 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
AHN, MI JA;NOH, JAE SEONG;SHIN, DONG SEONG |
分类号 |
C07D498/12;(IPC1-7):C07D498/12 |
主分类号 |
C07D498/12 |
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