| 摘要 |
Methods of inhibiting the proliferation of <i>Mycobacterium tuberculosis</i> comprising contacting <i>Mycobacterium tuberculosis</i> with an effective amount of a polynucleotide complementary to an mRNA transcript expressed by <i>Mycobacterium tuberculosis</i> are provided. Typical methods of the invention utilize phosphorothioate modified antisense polynucleotides (PS-ODNs) against the mRNA of M.tuberculosis genes such as glutamine synthetase, <i>aroA</i>,<i>ask</i>, <i>groES</i>, and the genes of the Antigen 85 complex. |
