| 摘要 |
The invention provides a method of identifying a compound useful for treatment of IBD which comprises assaying the compound for its ability to modulate the activity or amount of 3OST4. The assay is selected from measurement of 3OST4 activity using a cell line which expresses 3OST4 or using purified 3OST4 protein, and measurement of 3OST4 transcription or translation in a cell line expressing 3OST4. The invention also provides a method of preparing a pharmaceutical composition, a diagnostic method for the determination of susceptibility to IBD, a method for the diagnosis of IBD or a predisposition thereto and use of a compound able to modulate the activity or amount of 3OST4 in preparation of a medicament for the treatment of IBD. |
