摘要 |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH2-O- group. The compounds of the invention are represented by formula I:wherein A represent O, S or -CH2- attached at position 3, 4 or 6; Q is selected from the group consisting of:alpha represents O, S or NRs; beta, delta, gamma, mu and sigma represent CRt, N or N+Rs, provided that no more than one of beta, delta, gamma, mu and sigma is N+Rs, balanced by L- or a carboxylate anion. Salts and hydrates thereof are included. The iodo-substituted phenyl ring is further substituted with various substituent groups including at least one cationic group. Pharmaceutical compositions and methods of treatment are also included.
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