Ingestible device for the release of substances at district locations in alimentary canal

摘要

The field of the invention is site-specific drug delivery capsules (SSDC's). The disclosure relates to a closure member ( 14 ) for a substance reservoir ( 12 ) of an SSDC ( 10 ). The SSDC ( 10 ) includes a retainer that provides a non-linear force resisting opening of the closure member ( 14 ). The non-linear force ensures that the closure member ( 14 ) unseals the reservoir ( 12 ) only when an opening force exceeds a maximal value of the resisting force, thereby preventing premature or accidental emptying of the reservoir ( 12 ). The preferred means of providing the resistive force is a rolling, elastomeric o-ring ( 64 ) that additionally seals the closure member ( 14 ) into an aperture ( 13 ).