METHOD FOR PRODUCING CEPHALOSPORIN DERIVATIVES

摘要

PURPOSE: Provided is a method for producing cephalosporin derivatives which is useful as antibacterial agents having a strong antibacterial activity for various bacteria. CONSTITUTION: The cephalosporin derivatives having a strong antibacterial activity for various bacteria are represented by formula (I), in which R is aminothiazole, aminothiodiazole, alkylophenylthio; R1 is hydrogen, Na, K, diphenylmethyl; and R2 is phenyl and piperidylthiocarbonyl. The method for producing cephalosporin derivatives of formula (I) comprises the steps of: reacting thiol compounds represented by formula (III) with diphenylphosphoryloxy compounds represented by formula (II) to produce 3-cephem compounds represented by formula (IV); deacylating 3-cephem compounds of formula (IV) to produce 7-amino-3-cephem derivatives represented by formula (V); and acylating compounds of formula (VI) with compounds of formula (V) to produce the cephalosporin derivatives of formula (I).