| 摘要 |
Provided is a humanized, anti-Fas antibody-type molecule capable of, in cells having an abnormality in the Fas/Fas ligand system, (a) inducing apoptosis by binding Fas on the cell surface, and, in cells having no such abnormality, and (b) preventing apoptosis which would otherwise be induced by the binding of Fas ligand to the Fas antigen. Also provided are agents for treating conditions involving an abnormality in the Fas/Fas ligand system comprising the above antibody, DNA encoding the antibody, recombinant DNA vector comprising the DNA encoding the antibody, host cells transformed with the vector, culturing a host cell to produce the antibody, polypeptides constituting the antibody, DNA encoding the polypeptide, vectors comprising the DNA encoding the polypeptide and host cells transformed with the vector. |
