Substituted propane derivatives, process for their preparation and use of the compounds for the treatment of illnesses.

摘要

Propane derivs. of formula (I), and their salts, are new: D-B-A = opt. substd. propyl, omega -hydroxy- (1-4C)alkyl, OH, OT, phenyl or phenyl(1-3C)alkyl); R<1> = CN, COOH (opt. protected), 1-4C alkanoyl, SO3T, SO3H, SO2NR<5>R<6>, PO(OH)2, PO(OH)(OT), PO(OT)2 or tetrazol-5-yl; R<2> = 1-10C alkyl(R<8>)n, O-(1-10C)alkyl(R<8>)n, 2-10C alkenyl(R<8>)n, O-(3-10C)alkenyl(R<8>)n, 2-10C alkynyl(R<8>)n, O-(3-10C)alkynyl(R<8>)n, S-(1-10C)alkyl(R<8>)n, etc. (all R<8> gps. being opt. substd.); R<5>, R<6> = H, T, 1-4C alkanoyl or opt. substd. phenyl; or NR<5>R<6> = a 4-10 membered, satd. heterocyclic ring (in which one CH2 gp. is opt. replaced by O, S or NR<7>); R<7> = H, T, phenyl or benzyl; X = (CH2)m, CH=CH, C IDENTICAL C, CH2OCH2, CH2SCH2 or CH2-N(R<5>)-CH2; Y = (CH2)m, O, S or NR<5>; Z = (CH2)m, S, O, S-(1-10C)alkyl, O-(1-10C)alkyl, CH=CH, CH=CF, CH=CCl, CH=CBr, CH2CO, etc.; or when Y = O, the gp. C(O)ZR<3> may be an opt. protected amino acid residue; n = 0, 1 or 2; m = 0-4; R<3>, R<8> = 1-10C alkyl, 3-8C cycloalkyl, or opt. substd. Ar; T = 1-4C alkyl; Ar = phenyl, naphthyl, phenanthryl, pyridyl, thienyl, furyl, pyrimidyl, indolyl, etc.