| 摘要 |
Substituted dimeric compounds of Formula (I), to a process for their preparation and to the pharmaceutical compositions containing them, for treating pathologies associated with the melatoninergic system. Wherein, A represents a grouping of Formula (II); wherein Q represents a sulphur or oxygen atom; R1, R2 and R3, which may be identical or different, represent a hydrogen atom or a group Ra (wherein Ra represents an unsubstituted or substituted linear or branched C1-6alkyl group, an unsubstituted or substituted linear or branched C2-6alkenyl group, an unsubstituted or substituted linear or branched C2-6alkynyl group, an unsubstituted or substituted C3-8cycloalkyl group, an unsubstituted or substituted cycloalkyl-C3-8alkyl group in which the alkyl moiety is linear or branched, a polyhalo-C1-6alkyl group in which the alkyl moiety is linear or branched, an aryl group, an arylC1-6alkyl group in which the alkyl moiety is linear or branched, an arylC2-6alkenyl group in which the alkenyl moiety is linear or branched, a heteroaryl group, a heteroaryl-C1-6alkyl group in which the alkyl moiety is linear or branched or a heteroaryl-C2-6alkenyl group in which the alkenyl moiety is linear or branched), or the groups R2 and R3 can also form with the nitrogen atom carrying them a group selected from piperazinyl, piperidinyl and pyrrolidinyl; B represents a grouping of Formula (III); G1 and G3 which may be identical or different, represent a linear or branched alkylene chain containing from 1 to 4 carbon atoms that is optionally substituted by one or more identical or different groups selected from hydroxy, carboxy, formyl, Ra, ORa, COORa and CORa; Cy and Cy', which are different, represent a ring structure of the Formula (IV); wherein X and Y which may be identical or different, represent a sulphur, oxygen or carbon atom, or a CH or CH2 group, R4 represents a hydrogen or halogen atom, or a CF3, hydroxy, carboxy, formyl, amino, NHRa, NRaR1a, NHCORa, CONHRa, Ra, ORa, CORa or COORa group, wherein G2 substitutes the benzene ring, and G1 substitutes the ring containing X and Y in the case of Cy, and G2 substitutes the benzene ring and G3 substitutes the ring containing X and Y in the case of Cy', or a ring structure of Formula (V), wherein Z represents a sulphur or oxygen atom, or a CH2, NH, NSO2Ph or NRa group, D represents a benzene or pyridine ring, wherein G2 substitutes the D ring, and G1 substitutes the ring containing Z in the case of Cy, and G2 substitutes the D ring and G3 substitutes the ring containing Z in the case of Cy', G2 represents a chain of formula (VI), wherein W1, W2 and W3, which may be identical or different, represent a bond, an oxygen or sulphur atom, or a CH2, CHRa, NH or NRa group. n represents an integer 0=n=6, m represents an integer 0=m=6.
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