Preparation of 5-ribonucleotides seasoning agents

摘要

Preparing a 2', 3'-O-protected 5'-ribonucleotide by reacting a 2', 3'-O-protected 5'-ribonucleoside with phosphoryl chloride or tetrachloropyrophosphate in the presence of a trialkyl phosphate, and hydrolysing the resulting 2', 3'-O-protected 5'-ribonucleoside phosphorodichloridate. Removal of the protecting group or groups then gives the 5'-ribonucleotide (I). Cpds. (I) are seasoning agents and pharmaceuticals. The 5'-ribonucleoside is e.g. uridine, adenosine, guanosine, cytidine, inosine or xanthosine. Suitable protecting groups are isopropylidene, isobutylidene, cyclohexylidene, acetyl and benzoyl. The reaction with phosphoryl chloride or tetrachloropyrophosphate is suitably effected at temp. -15 deg.C to +25 deg.C.