| 发明名称 |
Delivery system for gene therapy to the brain |
| 摘要 |
A gene delivery system which is both safe and results in long-term expression throughout the brain has been developed. A lipid-entrapped, polycation-condensed DNA (LPD) system has been developed for brain gene delivery, using an adeno-associated viral ("AAV") vector in which the transcription unit is flanked by the 145 bp inverted terminal repeats (ITR) of the adeno-associated virus.
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| 申请公布号 |
NZ333334(A) |
申请公布日期 |
2001.06.29 |
| 申请号 |
NZ19980333334 |
申请日期 |
1998.04.17 |
| 申请人 |
FRANK L SORGI;PAOLA LEONE;MATTHEW J DURING |
发明人 |
LEONE, PAOLA;DURING, MATTHEW J;SORGI, FRANK L |
| 分类号 |
C12N15/09;A61K9/00;A61K9/127;A61K48/00;C12N9/88;C12N15/864;C12N15/87;C12N15/88;C12P21/02;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
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