Death domain containing receptor 5 and it's use in the treatment of DR5 related disease

摘要

An isolated polynucleotide encoding human Death Domain Containing Receptor 5 (DR5) comprising a first nucleic acid that is at least 90% identical to a second nucleic acid selected from SEQ ID NO:2. The amino acid sequences for the complete polypeptide and the mature polypeptide encoded by the cDNA clone are contained in ATCC Deposit No. 97920. Also described is a vector, a host cell and a pharmaceutical composition comprising the polypeptide. Disclosed is the use of polypeptide in the preparation of a medicament for the treatment of cancer, inflammation; autoimmune disease, viral infection, and graft vs. host disease. The translated polypeptide is a member of the TNF family of receptors. It binds TNF-related apoptosis-inducing ligand (TRAIL). Methods for producing a vector containing the polynucleotide, translating the polypeptide using a host cell, using the host cell to screen for ligand binding to polypeptide, identifying agonists and antagonists of the polypeptide, the production of antibody using the polypeptide, and the diagnosis of disease or susceptibility to disease related to underexpression of the polypeptide are disclosed.