4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]-indole-1-acetamide derivatives, their preparation and their application in therapy

摘要

Described are compounds of general formula (I) in which: X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group; Y represents a hydrogen atom, one or two halogen atoms or a methyl, hydroxy, methoxy or nitro group; R1 represents a hydrogen atom or a (C1-C4) alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom, a (C1-C4) alkyl group or a phenyl-methyl group; or R2 and R3 form, together with the nitrogen atom bearing them, an azetidinyl, pyrrolidinyl, 3-ethoxy-pyrrolidinyl, piperidinyl, morpholinyl, 4-methylpiperazinyl or 1,3-thiazolidinyl group. They can be used for treating diseases related to GABAergic transmission disorders, such as anxiety, sleep disorders, epilepsy, spasticity, muscle contractures, cognitive disorders related to alcoholism, tobacco or drugs, and the like.