2,4-Dioxo-thieno[2,3-d]pyrimidine derivatives useful as gonadotropin releasing hormone antagonists

摘要

A 2,4-dioxo-thieno[2,3-d]pyrimidine derivative or a salt thereof has the formula (I) wherein: R11 is H, alkyl or Q-(CH2)p-; Q is optionally substituted aryl; p is 1 to 3; R12 is H, alkyl or optionally substituted aryl, aralkyl or cycloalkyl; R13 is an optionally substituted amino; R14 is an optionally substituted aryl and r is 0-3. A pharmaceutical composition thereof is useful for treating or preventing a sex hormone dependent cancer, benign prostatic hypertrophy or myoma of the uterus.