| 摘要 |
Use of a replication incompetent herpes virus capable of delivering a gene t o multiple connected sites within the nervous system, which virus comprises: ( a) a mutation which prevents or reduces the expression of at least two immediat e early genes; and (b) a heterologous gene operably linked to a promoter activ e during herpes virus latency; in the manufacture of a medicament for the treatment of a central nervous system disorder, a method of determining whether a gene has an effect on a phenotype associated with a central nervou s system disorder and in a method of treatment of a disorder of the central nervous system.
|
