发明名称 |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE |
摘要 |
This invention relates to compounds of formula (I) that inhibit farnesylatio n of gene products through inhibition of the enzyme farnesyl-protein transfera se (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
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申请公布号 |
CA2388669(A1) |
申请公布日期 |
2001.06.28 |
申请号 |
CA20002388669 |
申请日期 |
2000.12.18 |
申请人 |
ASTRAZENECA AB |
发明人 |
WARDLEWORTH, JAMES MICHAEL;MATUSIAK, ZBIGNIEW;BOYLE, FRANCIS THOMAS |
分类号 |
A61K31/40;A61K31/454;A61K31/4545;A61P35/00;A61P35/02;A61P43/00;C07D207/12;C07D401/12;C07D401/14;(IPC1-7):C07D207/12;C07D207/00;C07D211/00 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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