SPIRO COMPOUNDS USEFUL AS OPIOID delta RECEPTOR AGONIST

摘要

Compounds of general formula (I) exhibiting affinity for opioid delta receptor, or salts thereof; and drugs containing the compounds or the salts as the active ingredient and being effective in the prevention and/or treatment of central nervous system diseases and peripheral nerve diseases wherein X is O, S, N or the like; n is 0, 1 or 2; the broken line represents the presence or absence of a bond; R<1> and R<3> are each independently hydrogen, halogeno, hydroxy, optionally substituted lower alkyl, or the like; and R<2> and R<4> are each independently hydrogen, optionally substituted lower alkyl, or the like.