发明名称 A PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF 2,2-DIALKYL-4-SUBSTITUTED PIPERIDINES
摘要 The present invention provides a process for preparing a compound of formula (I): wherein R<1> and R<2> each independently represent C1-C4 alkyl; and X represents an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II): wherein Q represents Cl or Br, with a suitable base followed by addition of a suitable Lewis acid and addition of a compound of formula R<->M<+> wherein M<+> is a suitable cation.
申请公布号 WO0146142(A1) 申请公布日期 2001.06.28
申请号 WO2000US32424 申请日期 2000.12.06
申请人 ELI LILLY AND COMPANY;HEATH, PERRY, CLARK 发明人 HEATH, PERRY, CLARK
分类号 C07D211/12;C07D409/04;(IPC1-7):C07D211/12;C07D211/22 主分类号 C07D211/12
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