发明名称 |
PHARMACEUTICAL COMPOSITION CONTAINING [1-{[1-(1,3-BENZODIOXOL-5-YLMETHYL)-1H-IMIDAZOL-5-YL]METHYL}-4-(1-NAPHTHYL)-1H-PYRROL-3-YL](4-METHYL-1-PIPERAZINYL)METHANONE |
摘要 |
The present invention relates to a pharmaceutical composition containing [1-{[1-(1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl}-4-(1-naphthyl)-1H-pyrrol-3-yl]-(4-methyl-1-piperazinyl)methanone, and more specifically, to the pharmaceutical composition containing the above compound in free form, or hydrates or solvates thereof, in admixture with a pharmaceutically acceptable additive selected from acidifier, solubilizing aids or buffer. Formulations prepared from such pharmaceutical composition have remarkably improved dissolution rate and pharmacokinetic characteristics, as compared with those containing the free compound alone, and have excellent chemical stability, which are very useful as orally administrable or injectable formulations. |
申请公布号 |
WO0145710(A1) |
申请公布日期 |
2001.06.28 |
申请号 |
WO2000KR01510 |
申请日期 |
2000.12.21 |
申请人 |
LG CHEMICAL LTD.;KIM, AE-RI;LEE, JIN-HWA;PARK, JAE-HYEON;LEE, SUN-HWA;LEE, SUNG-HACK |
发明人 |
KIM, AE-RI;LEE, JIN-HWA;PARK, JAE-HYEON;LEE, SUN-HWA;LEE, SUNG-HACK |
分类号 |
A61K31/41;A61K9/08;A61K9/20;A61K31/335;A61K31/357;A61K31/4164;A61K31/498;A61K31/50 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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