摘要 |
This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of formula (1) and pharmaceuitaclly acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention further relates to pharmaceutical compositions and dosage forms comprising compounds of formula (1) and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.
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申请人 |
SUGEN, INC.;LIANG, CONGXIN;SUN, LI;WEI, CHUNG, CHEN;TANG, PENG, CHO;MCMAHON, GERALD;HIRTH, KLAUS, PETER;CUI, JINGRONG |
发明人 |
LIANG, CONGXIN;SUN, LI;WEI, CHUNG, CHEN;TANG, PENG, CHO;MCMAHON, GERALD;HIRTH, KLAUS, PETER;CUI, JINGRONG |