发明名称 METHOD FOR MAKING HBED
摘要 The preparation of mono-cationic salt of N,N'-bis(2-hydroxybenzyl)- ethylenediamine-N,N'-diacetic acid (HBED) and HBED itself is disclosed. In particular, the invention relates to the hydrolysis of the t-butyl ester of HBED with a weak acid, such as formic acid, to form HBED, and the subsequent reaction with an equimolar amount of a base to form the mono-cationic salt.
申请公布号 WO0146114(A1) 申请公布日期 2001.06.28
申请号 WO2000US35321 申请日期 2000.12.21
申请人 GELTEX PHARMACEUTICALS, INC.;MCKEARIN, JAMES, M. 发明人 MCKEARIN, JAMES, M.
分类号 A61K31/195;A61K31/198;A61K45/06;C07C215/50;C07C227/02;C07C227/18;C07C229/16;C07C251/24;(IPC1-7):C07C53/00 主分类号 A61K31/195
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