ATTENUATED MUTANT ENTEROPATHOGENIC E. COLI (EPEC) STRAINS, PROCESS FOR THEIR PRODUCTION AND THEIR USE
摘要
The present invention relates to attenuated mammalian enteropathogenic <i>E. coli</i> (EPEC) strains comprising a deletion of an intimin encoding gene sequence wherein said deletion fully eliminates a functional intimin protein, which can be effectively used for the production of a vaccine against enteropathogenic <i>E. coli</i> (EPEC) infections in mammals. The invention also relates to recombinant vectors to be used in methods for the construction of said to attenuated mammalian enteropathogenic <i>E. coli</i> (EPEC) strains. The invention also relates to a method for in vitro differentiating between field infected and vaccinated individuals wherein said vaccinated individuals have been vaccinated with a vaccine comprising attenuated mammalian enteropathogenic <i>E. coli</i> (EPEC) strains having a deletion of an intimin gene sequence and said field infected individuals are <i>in vitro</i> diagnosed on the basis of the presence of intimin antibodies.
申请公布号
WO0073462(A3)
申请公布日期
2001.06.28
申请号
WO2000EP05061
申请日期
2000.06.02
申请人
CENTRUM VOOR ONDERZOEK IN DIERGENEESKUNDE EN AGROCHEMIE;MARIEN, JONAS;PEETERS, JOHAN;VANDEKERCHOVE, DOMINIQUE;STAKENBORG, WIM