| 发明名称 |
PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS |
| 摘要 |
Pyrazole compounds (I) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in t he treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed (I) wherein Y is O or NOH; Z is O or NH; R1 - R4 are as claimed .
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| 申请公布号 |
CA2395113(A1) |
申请公布日期 |
2001.06.28 |
| 申请号 |
CA20002395113 |
申请日期 |
2000.10.23 |
| 申请人 |
ICOS CORPORATION |
发明人 |
HERTEL, CARMEN C.;OLIVER, AMY;FOWLER, KERRY W.;MARTINS, TIMOTHY J. |
| 分类号 |
A61K31/415;A61K45/00;A61P5/14;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/02;A61P19/02;A61P19/10;A61P25/00;A61P25/24;A61P29/00;A61P31/04;A61P35/00;A61P35/02;A61P37/06;A61P37/08;C07D231/12;C07D231/14;C07D401/04;C07D401/12;(IPC1-7):C07D401/04;A61K31/44 |
主分类号 |
A61K31/415 |
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