发明名称 |
METHOD FOR THE PREPARATION OF 1-BENZOTRIAZOLYL CARBONATE ESTERS OF POLY(ETHYLENE GLYCOL) |
摘要 |
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotriazolylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid such as lysine, to form an amino acid derivative. |
申请公布号 |
WO0145796(A2) |
申请公布日期 |
2001.06.28 |
申请号 |
WO2000US34590 |
申请日期 |
2000.12.18 |
申请人 |
SHEARWATER CORPORATION;KOZLOWSKI, ANTONI |
发明人 |
KOZLOWSKI, ANTONI |
分类号 |
C12N9/96;A61K47/48;C08F8/30;C08G65/325 |
主分类号 |
C12N9/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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