发明名称 |
Aliphatic propargylamines as cellular rescue agents |
摘要 |
The present invention relates to the use of a group of propargylamines of the general formula (I)wherein R1 is hydrogen or CH3 and R2 is (CH2)nCH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.
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申请公布号 |
US6251950(B1) |
申请公布日期 |
2001.06.26 |
申请号 |
US19980110548 |
申请日期 |
1998.07.06 |
申请人 |
UNIVERSITY OF SASKATCHEWAN |
发明人 |
DURDEN DAVID;PATERSON ALICK;DAVIS BRUCE;DYCK LILLIAN;YU PETER;LI XINMIN;BOULTON ALAN |
分类号 |
A61P9/00;A61K31/13;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P43/00;C07C211/23;(IPC1-7):A61K31/13 |
主分类号 |
A61P9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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