| 摘要 |
1,210,345. L-asparaginase. KYOWA HAKKO KOGYO CO. Ltd. 29 May, 1969 [12 June, 1968], No. 27344/69. Heading C3H. In a process for purifying an enzymatic preparation of L-asparaginase obtained from an L - asparaginase - producing microorganism wherein said microorganism produces, together with the L-asparaginase, factors which inactivate the enzymatic activity of L-asparaginase, the activity of the L-asparaginase-inactivating factors is inhibited and the L-asparaginase preparation thereby stabilized during the purification process by adding to the L-asparaginase preparation silver, cadmium, copper, zinc or mercury ions, and purified L-asparaginase having an effective anti-tumour activity is recovered. The organism used may be Serratia marcescens. The metal ions may be added as an organic or inorganic salt of the metal.
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