发明名称 1-(N'-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands
摘要 Disclosed are compounds of the formulaor the pharmaceutically acceptable salts thereof whereinthe 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy;Ar represents optionally substituted aryl or heteroarylZ represents carbon or nitrogen provided thatwhere Z is carbon, R11 represents hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy, or phenyl optionally substituted with one or two groups selected from hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy; and where Z is nitrogen, R11 represents an electron pair;R5 is hydrogen or lower alkyl;m represents an integer;n is 0, or an integer;R12 and R13 independently represent lower alkyl;CR'R'' represent a methylene group optionally substituted with lower alkyl; andk is 1,which compounds are useful in treating various neuropsychological disorders including, for example, schizophrenia, dementia, depression, anxiety, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
申请公布号 US6252077(B1) 申请公布日期 2001.06.26
申请号 US19990470594 申请日期 1999.12.22
申请人 NEUROGEN CORPORATION 发明人 HE XIAO-SHU;DE COSTA BRIAN;WASLEY JAN W. F.
分类号 C07D209/44;C07D217/22;C07D401/12;C07D403/12;(IPC1-7):C07D209/40 主分类号 C07D209/44
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