BENZOPYRANYL GUANIDINE DERIVATIVES, ITS PRODUCING METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: Provided are the benzopyranyl guanidine derivatives, its producing method, and a pharmaceutical composition containing the same, therefore the pharmaceutical composition containing benzopyranyl guanidine derivatives can be used as heart protector, nerve cell protector, brain damage protector, storing internal organs protector, NO production inhibitor, antioxidative agent, novel blood vessel production inhibitor or vescular restenosis inhibitor. CONSTITUTION: The benzopyranyl guanidine derivatives are represented by formula (1), in which R1 is H, halogen, CF3, NO2, CN, ORa, COORa, NH2, NHS(O)mRa, NHCORa or S(O)mRa, wherein Ra is H, C1 to C4 linear or branched alkyl or aryl and m is an integer; R2 is C1 to C4 linear and branched alkyl; R3 is CH2ORa, ORbORc or O(Z)O, wherein Rb and Rc are independently C1 to C4 linear or branched alkyl, and Z is C1 to C5 linear or branched alkyl; R4 is OH, H, halogen, ONO2 or COORa; R5 and R6 are independently H, halogen, C1 to C3 linear or branched alkyl, ORa, CX3, NO2, CO2Ra, CORa or SO3Ra, wherein X is halogen; and n is an integer of 0 to 2.